Cinnamic acids and derivatives
Medchemexpress LLC (E)-Ethyl p-methoxycinnamate | 24393-56-4 | 99.4% | 206.24 | 1 ML
(E)-Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic, and anti-microbial effects. It acts as an inhibitor of COX-1 and COX-2 enzymes in vitro, with IC50 values of 1.12 μM and 0.83 μM, respectively. The product is intended for research use only and is not sold to patients.
- Natural product sourced from Kaempferia galangal.
- Exhibits anti-inflammatory, anti-neoplastic, and anti-microbial effects.
- Inhibits COX-1 (IC50: 1.12 μM) and COX-2 (IC50: 0.83 μM) in vitro.
- Shows moderate inhibitory activity against α-glucosidase (IC50: 50 μM).
- Inhibits migration and tubular structure formation in HUVECs.
- Exhibits cytotoxicity in various cancer cells.
- Induces apoptosis through caspase-3/7/8/9 activation in cancer cells.
- Inhibits bFGF and heparin-induced angiogenesis.
Medchemexpress LLC p-Coumaric acid-13C3 | 1261170-80-2 | 167.14 | 500 UG
p-Coumaric acid-13C3 is the 13C-labeled p-Coumaric acid, an abundant isomer of cinnamic acid known for its antitumor and anti-mutagenic activities.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Purity of 99.12%.
- Appears as a solid, white to off-white.
Medchemexpress LLC Ozagrel hydrochloride | 78712-43-3 | 99.9% | 50 MG
Ozagrel hydrochloride (OKY-046 hydrochloride) is a highly selective and orally active thromboxane A2 (TXA2) synthase inhibitor with an IC50 of 11 nM. It exerts anti-platelet aggregation, vasodilation, and anti-inflammatory effects by inhibiting TXA2 production and increasing prostacyclin (PGI2) production. This product is intended for research use only and can be utilized for studies related to ischemic stroke, asthma, and thromboembolic diseases.
- Highly selective and orally active thromboxane A2 (TXA2) synthase inhibitor
- Exerts anti-platelet aggregation effects
- Promotes vasodilation
- Provides anti-inflammatory effects
- Inhibits TXA2 production
- Increases prostacyclin (PGI2) production
- Useful for research in ischemic stroke
- Useful for research in asthma
- Useful for research in thromboembolic diseases
Medchemexpress LLC 3,4-Dimethoxycinnamic acid (O-methylferulic acid) | 2316-26-9 | 208.21 | 1 ML
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. It exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway.
- Monomer extracted and purified from securidaca inappendiculata hassk.
- Exerts anti-apoptotic effects on L-02 cells.
- Acts via the ROS-mediated signaling pathway.
- Attenuates ethanol-induced apoptosis in L-02 cells.
- Inhibits expression levels of Nox4 and p22phox.
- Decreases expression levels of superoxide dismutase, catalase, and phospholipid hydroperoxide gluthione peroxidase.
- Downregulates Bax/Bcl-2 and cleaved forms of caspase-3.
- For research use only.
![Research Products International Corp Trans-Cinnamic Acid [B-Phenylacrylic acid], 25 Grams](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-C34400-25.0.JPG-250.jpg)
Research Products International Corp Trans-Cinnamic Acid [B-Phenylacrylic acid], 25 Grams
Auxin like growth regulator.
Medchemexpress LLC Tyrphostin AG 879 | 148741-30-4 | 99.3% | 316.46 | 50 MG
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC. It also acts as a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, demonstrating at least 500-fold higher selectivity to ErbB2 than EGFR. This compound exhibits anticancer activity.
- Tyrosine kinase inhibitor
- Inhibits TrKA phosphorylation (IC50 of 10 μM), but not TrKB and TrKC
- Selective ErbB2 tyrosine kinase inhibitor (IC50 of 1 μM)
- At least 500-fold higher selectivity to ErbB2 than EGFR
- Anticancer activity
Apexbio Technology LLC Tyrphostin AG 1296 146535-11-7 100mg
Tyrphostin AG 1296 (CAS 146535-11-7) is a selective inhibitor of platelet-derived growth factor receptor (PDGFR) kinase via ATP-competitive binding Its inhibitory activity (IC50 0 3 0 5 M) results from inducing conformational changes in the ATP-binding domain of PDGFR blocking receptor autophosphorylation induced by ligand binding In vitro studies demonstrate inhibition of PDGF-stimulated mitogenesis (IC50 1 5 M) and cell proliferation (IC50 3 2 M) using Swiss 3T3 cells without significant effects on EGF receptor signaling at concentrations up to 100 M Tyrphostin AG 1296 serves as a research tool for investigating PDGFR-mediated signaling pathways
AdipoGen Curcumin high purity
Chemical. CAS 458-37-7. Formula C21H20O6. MW 368.4. Synthetic. Originally isolated from turmeric Curcuma longa. Anti-cancer compound. Interferes with multiple cell signaling pathways, including cell cycle cyclin D1 and cyclin E, apoptosis activation of caspases and down-regulation of anti-apoptotic gene products, proliferation HER-2, EGFR and AP-1, survival PI3K/AKT pathway, invasion MMP-9 and adhesion molecules, angiogenesis VEGF, metastasis CXCR-4 and inflammation NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX. Anti-angiogenic. Anti-metastatic. Anti-invasive. Chemopreventive. Sonic hedgehog Shh signaling pathway modulator. Downregulates Shh and Gli1. Antioxidant. Anti-inflammatory. Potent inhibitor of NF-kappaB, cyclooxygenase-2 COX-2, lipooxygenase LOX, and inducible nitric oxide synthase iNOS NOSII. Downregulates the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12 and chemokines. Potent immunomodulator.
Aobchem N-(3 4-difluorophenyl)methoxycarboxamide | 95% | CAS 225385-91-1 | C8H7F2NO2 | 10g
N-(3 4-difluorophenyl)methoxycarboxamide | 95% | CAS 225385-91-1 | C8H7F2NO2 | 10g
Aobchem 2 3-Difluorocinnamic acid | 95% | CAS 207981-48-4 | C9H6F2O2 | 100g
2 3-Difluorocinnamic acid | 95% | CAS 207981-48-4 | C9H6F2O2 | 100g